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Como si del juego de la oca se tratase, quienes juegan a Bacteriópolis se convierten en bacterias que avanzan por un tablero gigante hasta llegar a los laboratorios de la Fundación FISABIO. En las casillas especiales se aprende, por ejemplo, que los Lactobacillus convierten la leche en yogur o que algunas bacterias pueden ser resistentes a los antibióticos.
